Humans and Microbes

Bacteria and fungi play an essential role in the natural environment. They can degrade dead or discarded materials back to nature. In real life, people inevitably come into contact with various microorganisms such as bacteria and fungi. On the surface of human skin, the number of normal bacteria and fungi is 100 to 1,000 per square centimeter. Within this number range, they will not endanger human health or produce any odor. However, in daily life, human activities provide the best breeding place for microorganisms. Bacteria will multiply by tens of thousands without people paying attention, and may double every 20 minutes.The metabolism of microorganisms will produce bad odors and even infect humans to cause disease and death.

The War between Humans and Microbes

Traditional disinfection and cleaning techniques have proven to be very effective in killing harmful pathogens (bacteria, fungi, viruses, etc.) in the laboratory, but most of these techniques are fast and short-acting. At present, in most places, the frequency of disinfection and cleaning is far from the degree to completely inhibit the growth of bacteria.

The busy work and toxic disinfection chemicals make the disinfection work can only be operated in the gaps between daily operations, and the disinfection staff will occasionally cause some omissions under the pressure of time and tasks.These reasons cause the undesirable public health disinfection results in practice. Hospitals are undoubtedly one of the most polluted areas.

Serious Challenges

Infections and infectious diseases are a continuous threat to human health. According to the European Centre for Disease prevention and Control (ECDC), over 4 million people are estimated to acquire a HealthCare Associated Infection (HCAI).The number of deaths occurring as a direct consequence of these infections is estimated to be at least 37 000, and these infections are thought to contribute to an additional 110 000 deaths each year. In February 2015, the European Commission released a progress report on the 5 year action plan against the rising threats from Anti-Micriobial Resistance (AMR) that was initiated in 2013. Key actions are focussed on an appropriate use of antimicrobials, effective prevention of microbial infections, development of effective antimicrobials (antibiotics) or alternatives, e.g. Anti-Microbial nano Coating system (AMC) , joining forces with international partners, and reinforcing research to combat AMR in an innovative way.

Close Contacts and Infection

Whether it is influenza, SARS, MERS or the Wuhan coronavirus Covid-19, most of the transmission occurs between close contacts, and there are very few cases of all infections just by taking the same taxi or the same aircraft. There have been multiple reports of collective outbreaks living in the same hotel floor or in the same residential building during the SARS epidemic. This evidence proves that when carriers of pathogens continue to increase the virus concentration (air or surface) in the area, they will eventually lead to cross infection.The hand used to stop the cough droplets may press the elevator button. Few people will wash their hands immediately after using the hotel elevator or facilities. Some people may touch their noses, eyes, or even eat directly with their hands, which has led to exposure to deadly pathogens. Even wearing a mask in this case will not provide protection. Therefore, the anti-virus and anti-bacterial coating system (AMC) is a very potential technology to deal with such cases of outbreaks caused by close contact, because the virus’s transmission process in vitro may be blocked and the risk of infection will be restricted.

How to improve the level of public health and disease prevention?

Increase the frequency of disinfection

Such measures can reduce the risk of cross-infection in public health. For example, after the SARS epidemic, the Hong Kong MTR Corporation kept the disinfection every 4 hours as a routine procedure. However, measures that are limited by cost and actual operating environment are not suitable for many occasions.

Advanced antibacterial and antiviral hygienic surface

Now we can provide high-performance antibacterial and antiviral hygienic surfaces to the entire space through advanced surface coating system and treatment technology, thereby assisting traditional disinfection to achieve higher standards, reducing hospital cross infections, and protecting patients and medical staff.

The world is in action

In 2015, the AJIC [1] published a long-term research paper. Our US partner cooperated with Emory University in Atlanta and its affiliated Emory Healthcare Group [2] to using advanced hygienic surface technology. After 17 months of antibacterial and antiviral protection of one its affiliated hospital, the total cross infection rate of the hospital and the infection rates of different divisions in the hospital all showed a significant decreasing (P <0.05).

1.American Journal of Infection Control

As the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC). AJIC is the foremost resource on infection control, epidemiology, infectious diseases, quality management, occupational health, and disease prevention. AJIC also publishes infection control guidelines from APIC and the CDC. Infection control professionals, including physicians, nurses, and epidemiologists, rely on AJIC for peer- reviewed articles covering clinical topics as well as original research.

2.Emory University

Emory University has the 17th largest endowment among U.S. colleges and universities. It is ranked 21st nationally and 73rd globally according to U.S. News & World Report’s 2020 rankings.
Emory Healthcare, part of Emory University, is the largest health care system in the state of Georgia. It comprises ten hospitals, the Emory Clinic and more than 250 provider locations.

The AMICI-consortium [1] is convinced that new methods, in addition or as an alternative to an appropriate use of disinfectants and antibiotics, are required to reduce microbial activity, associated infections and the increase of AMR. There is an urgent need for the European Commission to expand their investments in these alternatives.A potential and promising weapon against bacterial growth and possibly the development of multi- drug resistant bacteria has been found in AntiMicrobial (nano)-Coatings (AMC).

Our partners in Europe participated in the AMICI research project, conducted basic research in several medical institutions and sites, and tapped the potential of AMC for infection risk control.

1. AMICI Consortium

With the support of the COST [2],, the scientific research institutions of EU member states form the AMICI consortium.

2. European Cooperation in Science and Technology「COST」
COST Action is a network dedicated to scientific collaboration, complementing national research funds. A COST Action is organized by a range of networking tools, such as meetings, conferences, workshops, short-term scientific missions, training schools, publications and dissemination activities.The average COST Action support is EUR 130,000 per annum for participation by typically 25 COST Members.

Our technology has been successfully applied to the metro and suburban railway system in Budapest, Hungary.After nearly a year of follow-up testing, the overall bacterial counts by ATP meter has decreased by more than 90%. As a prominent public health achievement, this result was presented to the Health Ministers of participating countries at 3rd CEEC-China Health Ministers’ Meeting [1] and its exhibition on June 19, 2017. The strategic cooperation agreement is signed under the witness of the Health Minister of China and the Economic Minister of Hungary to develop the Central and East European markets together.